Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23511435 | 0.86 | HDAC1 (0.56) | TP53TDP1HDAC1HDAC6KMT2A | |
| SCHEMBL23511678 | 0.84 | HDAC1 (0.51) | TP53TDP1HDAC1HDAC6KMT2A | |
| SCHEMBL23474252 | 0.82 | EPHX2 (0.50) | KMT2ACYP1A2CYP2C19CNR1CNR2 | |
| SCHEMBL23474257 | 0.81 | CSNK2A2 (0.55) | HDAC1HDAC6KMT2AALDH1A1RAB9A | |
| SCHEMBL10321485 | 0.75 | SMN1; SMN2 (0.59) | TP53KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL6092115 | 0.75 | HDAC1 (0.52) | TP53HDAC1HDAC6KMT2AALDH1A1 | |
| SCHEMBL14727425 | 0.74 | ALDH1A1 (0.68) | TP53TDP1KMT2AALDH1A1POLB | |
| SCHEMBL29994178 | 0.74 | ALDH1A1 (0.68) | TP53TDP1KMT2AALDH1A1POLB | |
| SCHEMBL6530703 | 0.73 | IKBKB (0.51) | TP53TDP1HDAC1HDAC6KMT2A | |
| SCHEMBL10321815 | 0.73 | SMN1; SMN2 (0.63) | TP53KMT2AALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021178902-A1 | METHODS OF INHIBITING MASP-2 FOR THE TREATMENT AND/OR PREVENTION OF CORONAVIRUS-INDUCED ACUTE RESPIRATORY DISTRESS SYNDROME | OMEROS CORPORATION (US) | 2021-09-10 | — | — | WO | disclosed |
| WO-2021113686-A1 | MASP-2 INHIBITORS AND METHODS OF USE | OMEROS CORPORATION (US) | 2021-06-10 | — | — | WO | disclosed |