Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511844 | 0.81 | CYP2C19 (0.51) | IKBKBMAPTMAPK8JAK2JAK3 | |
| SCHEMBL6514861 | 0.81 | DYRK1A (0.52) | IKBKBMAPTMAPK8JAK2JAK3 | |
| SCHEMBL23474255 | 0.73 | TP53 (0.54) | HDAC1HDAC6MAPTPOLBTP53 | |
| SCHEMBL10321814 | 0.73 | SMN1; SMN2 (0.60) | MAPTTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23511435 | 0.72 | HDAC1 (0.56) | HDAC1HDAC6MAPTPOLBTP53 | |
| SCHEMBL6506758 | 0.72 | IKBKB (0.50) | IKBKBMAPTJAK2JAK3TP53 | |
| SCHEMBL625881 | 0.72 | NPC1 (0.72) | POLBTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6507152 | 0.72 | IKBKB (0.57) | IKBKBHDAC6JAK2JAK3TDP1 | |
| SCHEMBL6506008 | 0.72 | IKBKB (0.56) | IKBKBHDAC6POLBJAK2JAK3 | |
| SCHEMBL23511678 | 0.71 | HDAC1 (0.51) | HDAC1HDAC6MAPTPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |