Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23459138 | 0.76 | POLB (0.44) | — | |
| SCHEMBL23477603 | 0.76 | POLB (0.44) | — | |
| SCHEMBL23459139 | 0.76 | POLB (0.44) | — | |
| SCHEMBL27499699 | 0.75 | CHRNA7 (0.56) | CHRM2CHRM4CHRM1CHRM3CHRNA7 | |
| SCHEMBL14438633 | 0.75 | CHRNB2 (0.45) | CHRNA7 | |
| SCHEMBL14438614 | 0.75 | CHRNB2 (0.45) | CHRNA7 | |
| SCHEMBL14438617 | 0.75 | CHRNB2 (0.45) | CHRNA7 | |
| SCHEMBL25698496 | 0.74 | PRKCG (0.53) | CHRM2CHRM4CHRM1CHRM3CHRNA7 | |
| SCHEMBL25698185 | 0.73 | SLC18A3 (0.52) | CHRM2CHRM4CHRM1CHRM3CHRNA7 | |
| SCHEMBL23477900 | 0.72 | GBA1 (0.44) | BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021113506-A1 | ATM KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. (US) | 2021-06-10 | — | — | WO | disclosed |