Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 11/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | ARNT | P27540 | 1/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29780231 | 0.78 | EPAS1 (0.41) | EPAS1 | |
| SCHEMBL23478762 | 0.78 | EPAS1 (0.41) | EPAS1 | |
| SCHEMBL29780217 | 0.69 | EPAS1 (0.39) | EPAS1MAPK1HTTMKNK1AURKA | |
| SCHEMBL23478125 | 0.69 | EPAS1 (0.39) | EPAS1MAPK1HTTMKNK1AURKA | |
| SCHEMBL23461094 | 0.67 | IDH1 (0.37) | AURKA | |
| SCHEMBL29780205 | 0.67 | IDH1 (0.37) | AURKA | |
| SCHEMBL23478387 | 0.65 | LMNA (0.35) | EPAS1HTT | |
| SCHEMBL29780196 | 0.63 | EPAS1 (0.42) | EPAS1 | |
| SCHEMBL23461602 | 0.63 | EPAS1 (0.42) | EPAS1 | |
| SCHEMBL23462206 | 0.62 | IDO1 (0.44) | BRAFEIF2AK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021113436-A1 | INHIBITORS OF HIF-2ALPHA | ARCUS BIOSCIENCES, INC. (US) | 2021-06-10 | — | — | WO | disclosed |