Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 8/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2354852 | 0.85 | TACR1 (0.40) | TACR1SLC6A4SLC6A2SLC6A3TLR9 | |
| SCHEMBL2349391 | 0.82 | TACR1 (0.44) | TACR1SLC6A4SLC6A2SLC6A3TAS1R3 | |
| SCHEMBL12469312 | 0.78 | SLC6A2 (0.46) | TACR1SLC6A4SLC6A2SLC6A3MEN1 | |
| SCHEMBL29017156 | 0.78 | GPR119 (0.38) | TACR1SLC6A4SLC6A2SLC6A3MEN1 | |
| SCHEMBL17560116 | 0.77 | TACR1 (0.41) | TACR1SLC6A4SLC6A2SLC6A3MEN1 | |
| SCHEMBL30502020 | 0.77 | GPR119 (0.40) | TACR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7503086 | 0.76 | ATR (0.40) | TAS1R3TAS1R1TAS1R2KMT2AATR | |
| SCHEMBL29799450 | 0.76 | ATR (0.40) | TAS1R3TAS1R1TAS1R2KMT2AATR | |
| SCHEMBL28952936 | 0.76 | TACR1 (0.40) | TACR1SLC6A4SLC6A2SLC6A3MEN1 | |
| SCHEMBL27808000 | 0.76 | TACR1 (0.40) | TACR1SLC6A4SLC6A2SLC6A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536710-A2 | PIPERIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011101304-A2 | PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-25 | — | — | WO | disclosed |