Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 6/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | RCE1 | Q9Y256 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | XDH | P47989 | 1/20 | 0.57 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL236627 | 0.88 | ALDH1A1 (0.60) | ALOX15ALOX12HSD17B10ALDH1A1KDM4E | |
| SCHEMBL18222914 | 0.85 | HSD17B10 (0.69) | HSD17B10ALDH1A1KDM4EHPGDRCE1 | |
| SCHEMBL30903615 | 0.85 | HSD17B10 (0.69) | HSD17B10ALDH1A1KDM4EHPGDRCE1 | |
| SCHEMBL18222890 | 0.84 | KDM4E (0.67) | ALOX15HSD17B10ALDH1A1KDM4EHPGD | |
| SCHEMBL30903612 | 0.84 | KDM4E (0.67) | ALOX15HSD17B10ALDH1A1KDM4EHPGD | |
| SCHEMBL234354 | 0.83 | ALOX15 (0.75) | ALOX15ALOX12HSD17B10ALDH1A1KDM4E | |
| SCHEMBL30903592 | 0.82 | KDM4E (0.74) | HSD17B10ALDH1A1KDM4EHPGDRCE1 | |
| SCHEMBL12325242 | 0.82 | KDM4E (0.74) | HSD17B10ALDH1A1KDM4EHPGDRCE1 | |
| SCHEMBL10563073 | 0.81 | MAPT (0.66) | ALOX15ALOX12HSD17B10ALDH1A1KDM4E | |
| SCHEMBL10562974 | 0.79 | ALOX15 (1.00) | ALOX15ALOX12HSD17B10ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120003273-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGISTRATION OF SOCIETIES ACT (ACT XXI OF 1860)) (IN) | 2012-01-05 | — | — | US | claimed |
| EP-2346844-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | Council Of Scientific & Industrial Research (IN) | 2011-07-27 | — | — | EP | claimed |
| WO-2010052734-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-05-14 | — | — | WO | claimed |
| EP-2346844-B1 | SUBSTITUTED BENZFUROCHROMENES FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL SCIENT IND RES (IN) | 2017-09-20 | — | — | EP | disclosed |
| EP-2346844-B1 | SUBSTITUTED BENZFUROCHROMENES FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL SCIENT IND RES (IN) | 2017-09-20 | — | — | EP | disclosed |
| US-20120003273-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGISTRATION OF SOCIETIES ACT (ACT XXI OF 1860)) (IN) | 2012-01-05 | — | — | US | disclosed |
| US-20120003273-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGISTRATION OF SOCIETIES ACT (ACT XXI OF 1860)) (IN) | 2012-01-05 | — | — | US | disclosed |
| US-20120003273-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGISTRATION OF SOCIETIES ACT (ACT XXI OF 1860)) (IN) | 2012-01-05 | — | — | US | disclosed |
| EP-2346844-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | Council Of Scientific & Industrial Research (IN) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010052734-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120003273-A1 | SUBSTITUTED BENZFUROCHROMENES AND RELATED COMPOUNDS FOR THE PREVENTION AND TREATMENT OF BONE RELATED DISORDERS | AKR1C3, AKR1C4, SLC10A1 | ALOX15 1264/4885ALOX12 1465/4885HSD17B10 247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.