Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 12/20 | 0.74 |
| ▸ | MAOA | P21397 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.58 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.56 |
| ▸ | RXRA | P19793 | 1/20 | 0.55 |
| ▸ | RXRB | P28702 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22721357 | 0.87 | MRGPRX4 (0.71) | MAOBALDH1A1HTTSMN1; SMN2MRGPRX4 | |
| SCHEMBL22721344 | 0.86 | MRGPRX4 (0.70) | SMN1; SMN2MRGPRX4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL22386765 | 0.85 | MRGPRX4 (0.55) | MAOBSMN1; SMN2MRGPRX4CYP19A1CYP11B1 | |
| SCHEMBL75853 | 0.85 | RAB9A (0.59) | MAOBSMN1; SMN2L3MBTL1 | |
| SCHEMBL22721364 | 0.85 | PARP10 (0.76) | MAOBMRGPRX4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL18002926 | 0.85 | MAOB (1.00) | MAOBMAOAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL22386764 | 0.83 | MRGPRX4 (0.53) | MAOBSMN1; SMN2MRGPRX4CYP19A1CYP11B1 | |
| SCHEMBL2087139 | 0.83 | MAOB (1.00) | MAOBMAOAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL20197040 | 0.83 | PPARD (0.54) | MAOBMAOAMRGPRX4RXRARXRB | |
| SCHEMBL20463314 | 0.83 | MAOB (0.52) | MAOBMAOAALDH1A1MRGPRX4CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018144900-A1 | SMALL MOLECULE ANTAGONISTS OF SUMO RELATED MODIFICATION OF CRMP2 AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2018-08-09 | — | — | WO | disclosed |
| US-8008487-B2 | Substituted thieno[2,3-D]pyrimidines as fungicides | DOW AGROSCIENCES LLC (US) | 2011-08-30 | — | — | US | disclosed |
| US-8008487-B2 | Substituted thieno[2,3-D]pyrimidines as fungicides | DOW AGROSCIENCES LLC (US) | 2011-08-30 | — | — | US | disclosed |
| US-8008487-B2 | Substituted thieno[2,3-D]pyrimidines as fungicides | DOW AGROSCIENCES LLC (US) | 2011-08-30 | — | — | US | disclosed |
| US-7423060-B2 | Thiophene hydroxamic acid derivatives and their use as HDAC inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2008-09-09 | — | — | US | disclosed |
| US-20080070976-A1 | Thiophene Hydroxamic Acid Derivatives and Their Use as Hdac Inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-20 | — | — | US | disclosed |
| EP-1758881-A1 | THIOPHENE HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HDAC INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-07 | — | — | EP | disclosed |
| US-20060089370-A1 | Thieno-pyrimidine compounds having fungicidal activity | BREWSTER WILLIAM K | 2006-04-27 | — | — | US | disclosed |
| WO-2005121120-A1 | THIOPHENE HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HDAC INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089370-A1 | Thieno-pyrimidine compounds having fungicidal activity | TYMP, DPM1, TYMS | MAOB 340/4885MAOA 551/4885ALDH1A1 539/4885 |
| US-20080070976-A1 | Thiophene Hydroxamic Acid Derivatives and Their Use as Hdac Inhibitors | HDAC1, HDAC5, HDAC2 | MAOB 1022/4885MAOA 740/4885ALDH1A1 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.