SCHEMBL75853

SCHEMBL75853

CC(=O)c1ccc(OC(F)(F)F)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.59
HPGD P15428 2/20 0.59
MAPT P10636 1/20 0.59
EPHX2 P34913 3/20 0.53
TRPV1 Q8NER1 3/20 0.53
L3MBTL1 Q9Y468 1/20 0.52
HDAC3 O15379 3/20 0.50
HDAC1 Q13547 3/20 0.50
HDAC2 Q92769 3/20 0.50
GAA P10253 1/20 0.50
MAOB P27338 1/20 0.50
HDAC4 P56524 2/20 0.49
HDAC7 Q8WUI4 2/20 0.49
HDAC10 Q969S8 2/20 0.49
HDAC11 Q96DB2 2/20 0.49
HDAC8 Q9BY41 2/20 0.49
HDAC6 Q9UBN7 2/20 0.49
HDAC9 Q9UKV0 2/20 0.49
HDAC5 Q9UQL6 2/20 0.49
NR1H4 Q96RI1 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25175292 0.94 RAB9A (0.70) RAB9AHPGDMAPTEPHX2TRPV1
SCHEMBL30837224 0.94 AURKA (0.54) RAB9AHPGDMAPTEPHX2TRPV1
Hydrochloric Acid SCHEMBL27796451 0.93 AURKA (0.53) RAB9AHPGDMAPTEPHX2TRPV1
SCHEMBL4880481 0.87 EPHX2 (0.78) RAB9AHPGDMAPTEPHX2TRPV1
SCHEMBL16168494 0.86 MAPT (0.57) RAB9AHPGDMAPTTRPV1L3MBTL1
SCHEMBL4883678 0.85 TRPV1 (0.76) RAB9AEPHX2TRPV1L3MBTL1HDAC3
SCHEMBL2348845 0.85 MAOB (0.74) L3MBTL1MAOBSMN1; SMN2
SCHEMBL4878398 0.85 TRPV1 (0.76) RAB9AEPHX2TRPV1L3MBTL1HDAC3
SCHEMBL2091503 0.84 MAPT (0.55) RAB9AHPGDMAPTL3MBTL1GAA
SCHEMBL14650795 0.84 TRPV1 (0.50) RAB9AHPGDEPHX2TRPV1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 573 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114805413-A Substituted phenyl tetraphenyl vinyl boron fluorine complex and preparation method and application thereof 河北科技大学 2022-07-29 CN claimed
EP-1421071-B1 SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS HIGH POINT PHARMACEUTICALS LLC (US) 2009-11-18 EP claimed
US-20060142262-A1 Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto ARENA PHARMACEUTICALS, INC. 2006-06-29 US claimed
US-20260124204-A1 METALLOENZYME INHIBITOR COMPOUNDS EIKONIZO THERAPEUTICS, INC. (US) 2026-05-07 US disclosed
US-20260098036-A1 2-HETEROARYL-3-OXO-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES FOR THE TREATMENT OF CANCER DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) 2026-04-09 US disclosed
US-12522594-B2 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) 2026-01-13 US disclosed
EP-4666856-A2 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO Corteva Agriscience LLC (US) 2025-12-24 EP disclosed
US-12490741-B2 Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto CORTEVA AGRISCIENCE LLC (US) 2025-12-09 US disclosed
US-12486218-B2 Compounds advantageous in the treatment of central nervous system diseases and disorders AURIMMED PHARMA, INC. (US) 2025-12-02 US disclosed
US-20250359552-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO CORTEVA AGRISCIENCE LLC (US) 2025-11-27 US disclosed
EP-3578543-B1 COMPOSITIONS COMPRISING MOLECULES HAVING PESTICIDAL UTILITY AND PROCESSES RELATED THERETO CORTEVA AGRISCIENCE LLC (US) 2025-08-20 EP disclosed
EP-0174769-A1 Antifungal azole compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-03-19 EP disclosed
EP-0163965-A2 Pyridazinones, their preparation and use, medicaments containing pyridazinones Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1985-12-11 EP disclosed
EP-0092627-B1 PROCESS FOR THE PREPARATION OF DI- OR TRIFLUOROMETHOXYPHENYL KETONES OR OF DI- OR TRIFLUOROMETHYLTHIOPHENYL KETONES RHONE-POULENC CHIMIE (FR) 1985-05-29 EP disclosed
EP-0066771-B1 1-IODO-1-PROPYN-3-OLS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PLANT PROTECTING AGENTS BAYER AG (DE) 1984-10-03 EP disclosed
US-4469902-A FUNGICIDES BAYER AKTIENGESELLSCHAFT (DE) 1984-09-04 US disclosed
US-4446078-A REACTING A POLYHALOALKOXY- OR POLYHALOALKYLTHIOBENZENE WITH A CARBOXYLIC DERIVATIVE, BORON TRIFLUORIDE RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1984-05-01 US disclosed
US-4438043-A Process for preparation of di- or trifluoromethoxyphenyl ketones or di- or trifluoromethylthiophenyl ketones RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1984-03-20 US disclosed
EP-0092627-A1 Process for the preparation of di- or trifluoromethoxyphenyl ketones or of di- or trifluoromethylthiophenyl ketones RHONE-POULENC CHIMIE (FR) 1983-11-02 EP disclosed
EP-0066771-A1 1-Iodo-1-propyn-3-ols, process for their preparation and their use as plant protecting agents BAYER AG (DE) 1982-12-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12486218-B2 Compounds advantageous in the treatment of central nervous system diseases and disorders SMN1; SMN2, HDAC6, CTSA RAB9A 748/4885HPGD 1231/4885MAPT 23/4885
US-20060142262-A1 Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto CYP7A1, CYP27A1, CYP4F3 RAB9A 1824/4885HPGD 378/4885MAPT 4217/4885
US-20260098036-A1 2-HETEROARYL-3-OXO-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES FOR THE TREATMENT OF CANCER AHR, CBR1, CNR1 RAB9A 2019/4885HPGD 1439/4885MAPT 4854/4885
US-20260124204-A1 METALLOENZYME INHIBITOR COMPOUNDS HDAC6, HDAC3, HDAC1 RAB9A 340/4885HPGD 2359/4885MAPT 2960/4885
US-20250359552-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO ACHE, DDT, MLYCD RAB9A 567/4885HPGD 997/4885MAPT 3431/4885
US-12490741-B2 Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto ACHE, DDT, MLYCD RAB9A 567/4885HPGD 997/4885MAPT 3431/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.