Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.58 |
| ▸ | RAF1 | P04049 | 2/20 | 0.58 |
| ▸ | BRAF | P15056 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1140199 | 0.89 | RAF1 (0.67) | MAPK14RAF1BRAFPKMMAPK1 | |
| SCHEMBL2352480 | 0.89 | PKM (0.70) | MAPK14RAF1BRAFPKMMAPK1 | |
| SCHEMBL12394214 | 0.87 | NPC1 (0.74) | MAPK14RAF1BRAFPKMMAPK1 | |
| SCHEMBL2346560 | 0.86 | RARA (0.66) | MAPK14RAF1BRAFPKMMAPK1 | |
| SCHEMBL1140320 | 0.85 | MAPK1 (0.61) | MAPK14RAF1BRAFPKMMAPK1 | |
| SCHEMBL2914953 | 0.85 | MAPK14 (0.62) | MAPK14RAF1BRAFPKMMAPK1 | |
| SCHEMBL1140770 | 0.85 | NPC1 (0.69) | MAPK14RAF1BRAFPKMMAPK1 | |
| SCHEMBL2353815 | 0.84 | PKM (0.63) | MAPK14RAF1BRAFPKMMAPK1 | |
| SCHEMBL2344162 | 0.84 | PKM (0.63) | MAPK14RAF1BRAFPKMMAPK1 | |
| SCHEMBL2913173 | 0.84 | PKM (0.65) | MAPK14RAF1BRAFPKMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008303-B2 | e.g. 6-Methyl-biphenyl-3,4'-dicarboxylic acid 4'-[(3-bromo-phenyl)-amide]-[(4 morpholin-4-yl-phenyl)-amide]; viricide; with other active viricide such as interferon or ribavirin | ASTRAZENECA AB (SE) | 2011-08-30 | — | — | US | disclosed |