Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.39 |
| ▸ | AKT1 | P31749 | 5/20 | 0.39 |
| ▸ | PRKCB | P05771 | 1/20 | 0.39 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.38 |
| ▸ | USP1 | O94782 | 3/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | KHK | P50053 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20371546 | 0.93 | RPS6KB1 (0.38) | RPS6KB1AKT1PRKCBRPS6KA1USP1 | |
| SCHEMBL14487641 | 0.81 | KHK (0.40) | RPS6KB1AKT1PRKCBRPS6KA1TLR8 | |
| SCHEMBL15730371 | 0.80 | TLR8 (0.39) | RPS6KB1AKT1PRKCBRPS6KA1TLR8 | |
| SCHEMBL15708454 | 0.80 | POLB (0.38) | RPS6KB1AKT1PRKCBRPS6KA1TLR8 | |
| SCHEMBL14487422 | 0.78 | HDAC6 (0.37) | RPS6KB1AKT1PRKCBRPS6KA1TLR8 | |
| SCHEMBL15723638 | 0.76 | TLR8 (0.37) | RPS6KB1AKT1PRKCBRPS6KA1TLR8 | |
| SCHEMBL14555675 | 0.74 | EPHX2 (0.38) | RPS6KB1AKT1PRKCBRPS6KA1GAA | |
| SCHEMBL14555677 | 0.73 | L3MBTL1 (0.37) | RPS6KB1AKT1PRKCBRPS6KA1GAA | |
| SCHEMBL15730562 | 0.73 | RPS6KB1 (0.34) | RPS6KB1AKT1PRKCBRPS6KA1TLR8 | |
| SCHEMBL1665141 | 0.71 | RPS6KB1 (0.52) | RPS6KB1AKT1PRKCBRPS6KA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230012449-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. | 2023-01-12 | — | — | US | disclosed |
| US-11034668-B2 | Compounds for the treatment of HIV | GILEAD SCIENCES, INC. (US) | 2021-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11034668-B2 | Compounds for the treatment of HIV | CCR5, NPC1, FURIN | RPS6KB1 1003/4885AKT1 1221/4885PRKCB 4266/4885 |
| US-20230012449-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | CCR5, NPC1, FURIN | RPS6KB1 1003/4885AKT1 1221/4885PRKCB 4266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.