Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.59 |
| ▸ | DDR2 | Q16832 | 6/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | APAF1 | O14727 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2347950 | 0.84 | DDR2 (0.62) | DDR2MAP4K4CLK2DYRK1ASRPK1 | |
| SCHEMBL2906655 | 0.82 | MAP4K4 (0.60) | MAPK14DDR2MAP4K4CLK2DYRK1A | |
| SCHEMBL14082953 | 0.81 | MAP4K4 (0.64) | MAP4K4CLK2DYRK1ASRPK1CLK4 | |
| SCHEMBL2348950 | 0.80 | MAPK14 (0.69) | MAPK14MAPTLMNAL3MBTL1KMT2A | |
| SCHEMBL12245667 | 0.77 | RAB9A (0.58) | MAP4K4CLK2DYRK1ACLK4MAPT | |
| SCHEMBL2566770 | 0.76 | NPC1 (0.65) | MAP4K4CLK2DYRK1ACLK4MAPT | |
| SCHEMBL2347535 | 0.75 | HSD17B10 (0.67) | MAPK14MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL2342393 | 0.75 | MAPK14 (0.71) | MAPK14DDR2MAPTLMNAKMT2A | |
| SCHEMBL4818436 | 0.74 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL13198179 | 0.74 | DDR2 (1.00) | MAPK14DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008303-B2 | e.g. 6-Methyl-biphenyl-3,4'-dicarboxylic acid 4'-[(3-bromo-phenyl)-amide]-[(4 morpholin-4-yl-phenyl)-amide]; viricide; with other active viricide such as interferon or ribavirin | ASTRAZENECA AB (SE) | 2011-08-30 | — | — | US | disclosed |