Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 6/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | CLK2 | P49760 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.60 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2906655 | 0.88 | MAP4K4 (0.60) | DDR2MAP4K4CLK2DYRK1ASRPK1 | |
| SCHEMBL2350752 | 0.84 | MAPK14 (0.59) | DDR2MAP4K4CLK2DYRK1ASRPK1 | |
| SCHEMBL2914486 | 0.80 | KMT2A (0.57) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL2342393 | 0.80 | MAPK14 (0.71) | DDR2MAPTALDH1A1NPC1LMNA | |
| SCHEMBL15764694 | 0.78 | NPC1 (0.76) | MAP4K4CLK2DYRK1ACLK4NPC1 | |
| SCHEMBL13198179 | 0.77 | DDR2 (1.00) | DDR2 | |
| SCHEMBL3378320 | 0.76 | RAB9A (0.80) | MAP4K4CLK2DYRK1ASRPK1CLK4 | |
| SCHEMBL29429758 | 0.76 | RAB9A (0.80) | MAP4K4CLK2DYRK1ASRPK1CLK4 | |
| SCHEMBL7369804 | 0.75 | NPC1 (0.82) | MAP4K4CLK2DYRK1ASRPK1CLK4 | |
| SCHEMBL2343132 | 0.75 | NPC1 (0.60) | ALDH1A1NPC1LMNARAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008303-B2 | e.g. 6-Methyl-biphenyl-3,4'-dicarboxylic acid 4'-[(3-bromo-phenyl)-amide]-[(4 morpholin-4-yl-phenyl)-amide]; viricide; with other active viricide such as interferon or ribavirin | ASTRAZENECA AB (SE) | 2011-08-30 | — | — | US | disclosed |