Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Strychnine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 0.91 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.91 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.91 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.66 |
| ▸ | GLRA1 | P23415 | 15/20 | 0.91 |
| ▸ | GLRB | P48167 | 13/20 | 0.91 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.91 |
| ▸ | MEN1 | O00255 | 2/20 | 0.91 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.91 |
| ▸ | TAS2R10 | Q9NYW0 | 2/20 | 0.91 |
| ▸ | TAS2R46 | P59540 | 1/20 | 0.91 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Strychnine SCHEMBL29729432 | 1.00 | GLRA1 (0.91) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL10983033 | 1.00 | GLRA1 (0.91) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL25257047 | 0.99 | GLRA1 (0.90) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL4957823 | 0.97 | GLRA1 (0.85) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL21985190 | 0.96 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL29362678 | 0.96 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL29352583 | 0.96 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL93798 | 0.96 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL12549549 | 0.96 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL14047653 | 0.96 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108524513-B | Application of strychnine sulfate, antibacterial composition, application of strychnine sulfate and antibacterial preparation | 湘潭大学 | 2020-04-07 | — | — | CN | claimed |
| CN-108524513-A | The application of strychnine sulfate and bacteria inhibiting composition and its application and inhibiting-bacteria preparation | 湘潭大学 | 2018-09-14 | — | — | CN | claimed |
| CN-107759601-A | A kind of preparation method of JAK inhibitor and its salt | 苏州旺山旺水生物医药有限公司 | 2018-03-06 | — | — | CN | claimed |
| CN-107759623-A | Intermediate of JAK inhibitor and preparation method thereof | 苏州旺山旺水生物医药有限公司 | 2018-03-06 | — | — | CN | claimed |
| EP-2380850-B1 | MODIFIED SODIUM-MONTMORILLONITE, PREPARING METHOD AND USES THEREOF | HAILISHENG PHARMACEUTICAL CO LTD (CN) | 2016-10-19 | — | — | EP | claimed |
| US-9095542-B2 | Modified sodium-montmorillonite, preparation method and uses thereof | HAILISHENG PHARMACEUTICAL CO., LTD (CN) | 2015-08-04 | — | — | US | claimed |
| CN-104072505-A | Method for extracting brucine and strychnine simultaneously | NANJING ZELANG MEDICAL TECH CO | 2014-10-01 | — | — | CN | claimed |
| EP-1747775-B1 | THE DISPERSIBLE MONTMORILLONITE TABLET AND ITS PREPARATION TECHNOLOGY | SHANDONG LUYE PHARM CO LTD (CN) | 2013-06-26 | — | — | EP | claimed |
| US-8337889-B2 | Smectite dispersible tablets and the preparation thereof | SHANDONG LUYE PHARMACEUTICAL CO., LTD. (CN) | 2012-12-25 | — | — | US | claimed |
| CN-101972259-B | Brucine and application of derivatives thereof in preparation of drugs for treating alcoholic abuse and dependence | UNIV BEIJING | 2012-04-25 | — | — | CN | claimed |
| US-20120003328-A1 | MODIFIED SODIUM-MONTMORILLONITE, PREPARATION METHOD AND USES THEREOF | HAILISHENG PHARMACEUTICAL CO., LTD (CN) | 2012-01-05 | — | — | US | claimed |
| EP-2380850-A1 | MODIFIED SODIUM-MONTMORILLONITE, PREPARING METHOD AND USES THEREOF | Hailisheng Pharmaceutical Co., Ltd (CN) | 2011-10-26 | — | — | EP | claimed |
| US-20080038337-A1 | Smectite DispersibleTablets and the Preparation Thereof | SHANDONG LUYE PHARMACEUTICAL CO., LTD. (CN) | 2008-02-14 | — | — | US | claimed |
| EP-1747775-A1 | THE DISPERSIBLE MONTMORILLONITE TABLET AND ITS PREPARATION TECHNOLOGY | SHANDONG LUYE PHARMACEUTICAL CO., LTD. (CN) | 2007-01-31 | — | — | EP | claimed |
| CN-1280158-C | Household products based on petroleum distillate | JOHNSON & SON INC S C (US) | 2006-10-18 | — | — | CN | claimed |
| CN-1589218-A | Household products based on petroleum distillate | JOHNSON & SON INC S C (US) | 2005-03-02 | — | — | CN | claimed |
| CN-111050688-B | Waste disposal system and waste receptacle for receiving and disposing of pharmaceutical waste | 史赛克公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-115282190-A | A skin antibacterial liquid containing plant extract and its preparation method | 王瑶英 | 2022-11-04 | — | — | CN | disclosed |
| US-3935211-A | CNS DEPRESSANT | AMERICAN CYANAMID COMPANY (US) | 1976-01-27 | — | — | US | disclosed |
| US-3933794-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS | THE UPJOHN COMPANY (US) | 1976-01-20 | — | — | US | disclosed |