Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6627628 | 0.81 | KDM4E (0.64) | LMNASMN1; SMN2HTTALDH1A1KDM4E | |
| SCHEMBL3718479 | 0.81 | KDM4E (0.64) | LMNASMN1; SMN2HTTALDH1A1KDM4E | |
| SCHEMBL14074899 | 0.80 | KDM4E (0.62) | LMNASMN1; SMN2HTTALDH1A1KDM4E | |
| SCHEMBL13435159 | 0.78 | LMNA (0.59) | LMNASMN1; SMN2HTTALDH1A1KDM4E | |
| SCHEMBL8283153 | 0.78 | LMNA (0.59) | LMNASMN1; SMN2HTTALDH1A1KDM4E | |
| SCHEMBL962133 | 0.78 | OPRM1 (0.62) | LMNASMN1; SMN2HTTALDH1A1KDM4E | |
| SCHEMBL12946592 | 0.76 | SMN1; SMN2 (0.71) | LMNASMN1; SMN2HTTALDH1A1KDM4E | |
| SCHEMBL16864106 | 0.76 | LMNA (0.72) | LMNASMN1; SMN2HTTALDH1A1KDM4E | |
| SCHEMBL17535986 | 0.75 | LMNA (0.67) | LMNASMN1; SMN2HTTALDH1A1KDM4E | |
| SCHEMBL13757095 | 0.75 | LMNA (0.67) | LMNASMN1; SMN2HTTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021115286-A1 | SIX-MEMBERED AND FIVE-MEMBERED AROMATIC RING DERIVATIVE CONTAINING NITROGEN HETEROATOMS WHICH CAN BE USED AS SHP2 INHIBITOR | 成都倍特药业股份有限公司 | 2021-06-17 | — | — | WO | disclosed |