Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HTR1E | P28566 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.46 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.46 |
| ▸ | ITGAL | P20701 | 2/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10664287 | 0.85 | CYP3A4 (0.49) | HTR1DHTR2CHTR1EHTR2BHTR2A | |
| SCHEMBL13897023 | 0.85 | CYP3A4 (0.49) | HTR1DHTR2CHTR1EHTR2BHTR2A | |
| SCHEMBL18748750 | 0.85 | CYP3A4 (0.49) | ALDH1A1CYP3A4CYP1A2CYP2C19SLC7A5 | |
| SCHEMBL1666697 | 0.85 | ALDH1A1 (0.58) | ALDH1A1CYP3A4CYP1A2CYP2C19SLC7A5 | |
| SCHEMBL23901492 | 0.84 | CYP3A4 (0.48) | HTR1DHTR2CHTR1EHTR2BHTR2A | |
| SCHEMBL23513654 | 0.83 | HRH3 (0.47) | HTR1DHTR2CHTR1EHTR2BHTR2A | |
| SCHEMBL23387015 | 0.83 | HRH3 (0.47) | ALDH1A1CYP3A4CYP1A2CYP2C19SLC7A5 | |
| SCHEMBL5808674 | 0.83 | HTR1D (0.51) | HTR1DHTR2CHTR1EHTR2BHTR2A | |
| SCHEMBL20093553 | 0.83 | HRH3 (0.47) | HTR1DHTR2CHTR1EHTR2BHTR2A | |
| SCHEMBL13912170 | 0.83 | HRH3 (0.47) | HTR1DHTR2CHTR1EHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210179580-A1 | PYRIMIDINE DERIVATIVES AS INHIBITORS OF PD1/PD-L1 ACTIVATION | Jubilant Prodel LLC | 2021-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210179580-A1 | PYRIMIDINE DERIVATIVES AS INHIBITORS OF PD1/PD-L1 ACTIVATION | PDCD1, CD274, PDCD1LG2 | HTR1D 427/4885HTR2C 3447/4885HTR1E 1770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.