Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 15/20 | 0.42 |
| ▸ | JAK2 | O60674 | 12/20 | 0.42 |
| ▸ | JAK1 | P23458 | 9/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.38 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.38 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23513567 | 0.86 | KDM5A (0.40) | KDM5AJAK3JAK2JAK1TYK2 | |
| SCHEMBL26286124 | 0.84 | JAK2 (0.41) | KDM5AJAK3JAK2JAK1TYK2 | |
| SCHEMBL19229772 | 0.81 | EPHX2 (0.55) | CYP2D6MCHR1 | |
| SCHEMBL16718811 | 0.80 | JAK3 (0.42) | KDM5AJAK3JAK2JAK1TYK2 | |
| SCHEMBL12463610 | 0.79 | JAK3 (0.49) | JAK3JAK2JAK1 | |
| SCHEMBL13740949 | 0.79 | ALDH1A1 (0.42) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL12384552 | 0.79 | ALDH1A1 (0.42) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL24775473 | 0.78 | CYP2D6 (0.44) | CYP2D6MCHR1 | |
| SCHEMBL12384243 | 0.78 | JAK2 (0.39) | JAK3JAK2JAK1TYK2KCNH2 | |
| SCHEMBL16718806 | 0.78 | ALDH1A1 (0.42) | KDM5AJAK3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210179580-A1 | PYRIMIDINE DERIVATIVES AS INHIBITORS OF PD1/PD-L1 ACTIVATION | Jubilant Prodel LLC | 2021-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210179580-A1 | PYRIMIDINE DERIVATIVES AS INHIBITORS OF PD1/PD-L1 ACTIVATION | PDCD1, CD274, PDCD1LG2 | KDM5A 1442/4885JAK3 1914/4885JAK2 1323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.