Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.41 |
| ▸ | JAK3 | P52333 | 16/20 | 0.41 |
| ▸ | JAK1 | P23458 | 8/20 | 0.41 |
| ▸ | TYK2 | P29597 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | MARK3 | P27448 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.39 |
| ▸ | STK3 | Q13188 | 2/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.39 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.39 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12463610 | 0.91 | JAK3 (0.49) | JAK2JAK3JAK1 | |
| SCHEMBL16718806 | 0.90 | ALDH1A1 (0.42) | JAK2JAK3JAK1TYK2KCNH2 | |
| SCHEMBL23513629 | 0.84 | KDM5A (0.43) | JAK2JAK3JAK1TYK2KCNH2 | |
| SCHEMBL16718811 | 0.83 | JAK3 (0.42) | JAK2JAK3JAK1TYK2KCNH2 | |
| SCHEMBL3685041 | 0.80 | JAK3 (0.48) | JAK2JAK3JAK1TYK2ROCK1 | |
| SCHEMBL1848016 | 0.80 | JAK3 (0.48) | JAK2JAK3JAK1TYK2ROCK1 | |
| SCHEMBL23513567 | 0.80 | KDM5A (0.40) | JAK2JAK3JAK1TYK2KCNH2 | |
| SCHEMBL16408220 | 0.80 | HRH4 (0.39) | KDM1A | |
| SCHEMBL2215861 | 0.80 | HRH4 (0.39) | KDM1A | |
| SCHEMBL14045029 | 0.80 | EPHX2 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023172737-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | KUMQUAT BIOSCIENCES INC. (US) | 2023-09-14 | — | — | WO | disclosed |