Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CTSC | P53634 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870277 | 0.89 | CYP2C19 (0.58) | CYP2C19RAB9AALDH1A1CTSCNPC1 | |
| SCHEMBL19790141 | 0.88 | RAB9A (0.52) | CYP2C19RAB9AALDH1A1CTSCNPC1 | |
| SCHEMBL8248802 | 0.87 | CYP2C19 (0.55) | CYP2C19RAB9AALDH1A1CTSCPKM | |
| SCHEMBL5870011 | 0.87 | CYP2C19 (0.55) | CYP2C19RAB9AALDH1A1CTSCPKM | |
| SCHEMBL7223221 | 0.86 | CYP2C19 (0.58) | CYP2C19RAB9AALDH1A1CTSCNPC1 | |
| SCHEMBL14010003 | 0.86 | RAB9A (0.51) | CYP2C19RAB9AALDH1A1CTSCNPC1 | |
| SCHEMBL19483469 | 0.86 | RAB9A (0.51) | CYP2C19RAB9AALDH1A1CTSCNPC1 | |
| SCHEMBL15185809 | 0.85 | RAB9A (0.50) | CYP2C19RAB9AALDH1A1CTSCNPC1 | |
| SCHEMBL8188457 | 0.84 | CYP2C19 (0.64) | CYP2C19RAB9AALDH1A1CTSCNPC1 | |
| SCHEMBL14019361 | 0.84 | CYP2C19 (0.64) | CYP2C19RAB9AALDH1A1CTSCNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210179580-A1 | PYRIMIDINE DERIVATIVES AS INHIBITORS OF PD1/PD-L1 ACTIVATION | Jubilant Prodel LLC | 2021-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210179580-A1 | PYRIMIDINE DERIVATIVES AS INHIBITORS OF PD1/PD-L1 ACTIVATION | PDCD1, CD274, PDCD1LG2 | CYP2C19 153/4885RAB9A 1435/4885ALDH1A1 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.