Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA3 | P07451 | 2/20 | 0.32 |
| ▸ | CA4 | P22748 | 2/20 | 0.32 |
| ▸ | CA6 | P23280 | 2/20 | 0.32 |
| ▸ | CA5A | P35218 | 2/20 | 0.32 |
| ▸ | CA7 | P43166 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL408093 | 0.78 | HTT (0.50) | HTTHSD17B10GAANPSR1L3MBTL1 | |
| Bromide SCHEMBL7406625 | 0.71 | HTT (0.43) | HTTHSD17B10GAANPSR1L3MBTL1 | |
| SCHEMBL2890226 | 0.67 | F2 (0.39) | HTTL3MBTL1RAB9ACA12CA1 | |
| SCHEMBL10125972 | 0.66 | PIK3CG (0.57) | SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL1640359 | 0.66 | ALDH1A1 (0.34) | HTTHSD17B10GAARAB9ACA12 | |
| SCHEMBL18256147 | 0.65 | GAA (0.43) | HTTHSD17B10GAAL3MBTL1NPC1 | |
| SCHEMBL3008519 | 0.64 | HSD17B10 (0.57) | HTTHSD17B10NPSR1NPC1RAB9A | |
| SCHEMBL13208839 | 0.64 | HSD17B10 (0.45) | HTTHSD17B10NPC1RAB9AKDM4E | |
| SCHEMBL11325797 | 0.63 | RAB9A (0.59) | HTTGAAL3MBTL1NPC1RAB9A | |
| SCHEMBL4028624 | 0.62 | MAPT (0.62) | HTTHSD17B10GAAL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021116260-A1 | QUINAZOLINE DERIVATIVES AS LPA RECEPTOR 2 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2021-06-17 | — | — | WO | disclosed |