Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15743960 | 0.83 | TSHR (0.72) | TSHRSMN1; SMN2LMNAMEN1CYP3A4 | |
| SCHEMBL9921691 | 0.78 | ATM (0.76) | TSHRSMN1; SMN2LMNAALDH1A1ATM | |
| SCHEMBL17409799 | 0.77 | GSK3B (0.58) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL28487695 | 0.77 | SMN1; SMN2 (0.56) | TSHRSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL17409797 | 0.76 | TSHR (0.58) | TSHRSMN1; SMN2LMNAEGFRHTT | |
| SCHEMBL20947437 | 0.74 | GSK3B (0.72) | SMN1; SMN2HTTGSK3BDYRK1A | |
| SCHEMBL13662043 | 0.73 | TSHR (0.69) | TSHRSMN1; SMN2LMNAALDH1A1EGFR | |
| SCHEMBL2099004 | 0.72 | LMNA (0.62) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL15986711 | 0.72 | TSHR (0.72) | TSHRSMN1; SMN2LMNAALDH1A1ATM | |
| SCHEMBL30648834 | 0.72 | TSHR (0.72) | TSHRSMN1; SMN2LMNAALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11572359-B2 | PARP/PI3K double-target inhibit containing pyridopyrimidine structure | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2023-02-07 | — | — | US | disclosed |
| US-20210179610-A1 | PARP/PI3K DOUBLE-TARGET INHIBITOR CONTAINING PYRIDOPYRIMIDINE STRUCTURE | HEFEI INDUSTRIAL PHARMACEUTICAL INSTITUTE CO., LTD. (CN) | 2021-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11572359-B2 | PARP/PI3K double-target inhibit containing pyridopyrimidine structure | PARP2, PARP1, PIK3CA | TSHR 3994/4885SMN1; SMN2 3422/4885LMNA 1529/4885 |
| US-20210179610-A1 | PARP/PI3K DOUBLE-TARGET INHIBITOR CONTAINING PYRIDOPYRIMIDINE STRUCTURE | PARP2, PARP1, PIK3CA | TSHR 3939/4885SMN1; SMN2 3280/4885LMNA 1544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.