Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | NPC1 | O15118 | 6/20 | 0.68 |
| ▸ | RAB9A | P51151 | 6/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | PKM | P14618 | 2/20 | 0.68 |
| ▸ | QSOX1 | O00391 | 1/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2353892 | 0.95 | RAB9A (0.63) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2354088 | 0.88 | MAPT (0.59) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL1140174 | 0.87 | RAF1 (0.65) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2349159 | 0.86 | MAPT (0.66) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2348445 | 0.85 | MAPT (0.53) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2344354 | 0.85 | MAPT (0.55) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2348835 | 0.85 | MAPT (0.59) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2345583 | 0.84 | ALDH1A1 (0.56) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2351869 | 0.83 | MAPT (0.55) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2342770 | 0.83 | RAF1 (0.69) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008303-B2 | e.g. 6-Methyl-biphenyl-3,4'-dicarboxylic acid 4'-[(3-bromo-phenyl)-amide]-[(4 morpholin-4-yl-phenyl)-amide]; viricide; with other active viricide such as interferon or ribavirin | ASTRAZENECA AB (SE) | 2011-08-30 | — | — | US | disclosed |