Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 2/20 | 0.62 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.55 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.55 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.55 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.50 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.50 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | PRCP | P42785 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | RHEB | Q15382 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10030830 | 0.88 | PRKAG1 (0.54) | CACNA1GCACNA1HCACNA1BCACNA1CPRKAG1 | |
| SCHEMBL4149629 | 0.85 | CACNA1H (0.53) | CACNA1GCACNA1HCACNA1BCACNA1CGAA | |
| SCHEMBL15243340 | 0.85 | CACNA1H (0.53) | CACNA1GCACNA1HCACNA1BCACNA1CBCHE | |
| SCHEMBL19494569 | 0.81 | SMN1; SMN2 (0.62) | CACNA1HCACNA1BCACNA1CBCHESMN1; SMN2 | |
| SCHEMBL30313258 | 0.81 | CACNA1H (0.54) | CACNA1GCACNA1HCACNA1BCACNA1CBCHE | |
| SCHEMBL25155380 | 0.81 | CACNA1H (0.51) | CACNA1GCACNA1HCACNA1BCACNA1CBCHE | |
| SCHEMBL31360370 | 0.81 | CACNA1H (0.51) | CACNA1GCACNA1HCACNA1BCACNA1CBCHE | |
| SCHEMBL15584882 | 0.81 | CACNA1H (0.53) | CACNA1GCACNA1HCACNA1BCACNA1CGAA | |
| SCHEMBL15584671 | 0.81 | CACNA1H (0.53) | CACNA1GCACNA1HCACNA1BCACNA1CBCHE | |
| SCHEMBL23731882 | 0.81 | CACNA1H (0.53) | CACNA1HCACNA1BCACNA1CHTTEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11666578-B2 | Small molecule inhibitors of CDK12/CDK13 | THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2023-06-06 | — | — | US | disclosed |
| US-11666578-B2 | Small molecule inhibitors of CDK12/CDK13 | THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2023-06-06 | — | — | US | disclosed |
| US-11666578-B2 | Small molecule inhibitors of CDK12/CDK13 | THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2023-06-06 | — | — | US | disclosed |
| US-20210186979-A1 | SMALL MOLECULE INHIBITORS OF CDK12/CDK13 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-06-24 | — | — | US | disclosed |
| US-20210186979-A1 | SMALL MOLECULE INHIBITORS OF CDK12/CDK13 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210186979-A1 | SMALL MOLECULE INHIBITORS OF CDK12/CDK13 | CDK12, CDK1, CDK13 | CACNA1G 4318/4885CACNA1H 4453/4885CACNA1B 4047/4885 |
| US-11666578-B2 | Small molecule inhibitors of CDK12/CDK13 | CDK12, CDK1, CDK13 | CACNA1G 4318/4885CACNA1H 4453/4885CACNA1B 4047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.