Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 1/20 | 0.54 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.54 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.54 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.54 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | F9 | P00740 | 2/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.43 |
| ▸ | STK17B | O94768 | 1/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23522706 | 0.88 | CACNA1G (0.62) | PRKAG1PRKAA2PRKAA1PRKAB1CACNA1G | |
| SCHEMBL19378074 | 0.86 | BCHE (0.49) | HTTBCHELMNASMN1; SMN2TP53 | |
| SCHEMBL19408069 | 0.86 | F9 (0.55) | HTTBCHELMNASMN1; SMN2TP53 | |
| SCHEMBL16176294 | 0.81 | PRKAG1 (0.68) | PRKAG1PRKAA2PRKAA1PRKAB1CACNA1G | |
| SCHEMBL6304380 | 0.81 | BCHE (0.69) | HTTGAABCHELMNASMN1; SMN2 | |
| SCHEMBL25926140 | 0.81 | APEX1 (0.58) | HTTBCHELMNASMN1; SMN2F9 | |
| SCHEMBL19408133 | 0.80 | BCHE (0.46) | HTTGAABCHELMNASMN1; SMN2 | |
| SCHEMBL13406081 | 0.75 | TP53 (0.66) | LMNASMN1; SMN2TP53F9HPGD | |
| SCHEMBL16186541 | 0.75 | CACNA1G (0.55) | PRKAG1PRKAA2PRKAA1PRKAB1CACNA1G | |
| SCHEMBL15173223 | 0.74 | BRD4 (0.49) | HTTGAABCHECACNA1HCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028975-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND ANALOGS THEREOF | SCHERING CORPORATION | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028975-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND ANALOGS THEREOF | PDE2A, PDE5A, PDE4A | PRKAG1 155/4885PRKAA2 153/4885PRKAA1 154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.