Sugi Predict

Sugi Predict / Compounds / SCHEMBL23524488

SCHEMBL23524488

SCHEMBL23524488

Cc1cc(C(=O)CN2CCCCC2)c(C)n1[C@H]1CC[C@H](C(=O)O)CC1

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ NOTUM Q6P988 1/20 0.53
▸ NPC1 O15118 11/20 0.52
▸ RAB9A P51151 11/20 0.52
▸ ALDH1A1 P00352 4/20 0.52
▸ MEN1 O00255 3/20 0.52
▸ KMT2A Q03164 3/20 0.52
▸ ATM Q13315 1/20 0.52
▸ L3MBTL1 Q9Y468 1/20 0.52
▸ SMN1; SMN2 Q16637 5/20 0.51
▸ HPGD P15428 2/20 0.51
▸ KDM4E B2RXH2 4/20 0.50
▸ USP14 P54578 3/20 0.49
▸ USP7 Q93009 2/20 0.49
▸ USP5 P45974 1/20 0.49
▸ LMNA P02545 1/20 0.45
▸ PKM P14618 1/20 0.45
▸ CRHBP P24387 1/20 0.44
▸ CRHR2 Q13324 1/20 0.44
▸ MAPT P10636 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23292726 1.00 NOTUM (0.53) NOTUMNPC1RAB9AALDH1A1MEN1
SCHEMBL23524479 1.00 NOTUM (0.53) NOTUMNPC1RAB9AALDH1A1MEN1
SCHEMBL23292725 0.89 RAB9A (0.51) NOTUMNPC1RAB9AALDH1A1MEN1
SCHEMBL23524508 0.89 RAB9A (0.51) NOTUMNPC1RAB9AALDH1A1MEN1
SCHEMBL23524501 0.89 RAB9A (0.51) NOTUMNPC1RAB9AALDH1A1MEN1
SCHEMBL23524560 0.89 SMN1; SMN2 (0.60) NOTUMNPC1RAB9AALDH1A1MEN1
SCHEMBL23524556 0.89 SMN1; SMN2 (0.60) NOTUMNPC1RAB9AALDH1A1MEN1
SCHEMBL23559526 0.88 NPC1 (0.54) NOTUMNPC1RAB9AALDH1A1MEN1
SCHEMBL23524541 0.87 RAB9A (0.53) NOTUMNPC1RAB9AALDH1A1MEN1
SCHEMBL23524538 0.87 RAB9A (0.53) NOTUMNPC1RAB9AALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240116894-A1 PROTEASOME ACTIVITY ENHANCING COMPOUNDS Kineta, Inc. 2024-04-11 — — US disclosed
US-11746098-B2 Proteasome activity enhancing compounds PROTEOSTASIS THERAPEUTICS, INC. (US) 2023-09-05 — — US disclosed
US-11746098-B2 Proteasome activity enhancing compounds PROTEOSTASIS THERAPEUTICS, INC. (US) 2023-09-05 — — US disclosed
US-11746098-B2 Proteasome activity enhancing compounds PROTEOSTASIS THERAPEUTICS, INC. (US) 2023-09-05 — — US disclosed
US-20210188802-A1 PROTEASOME ACTIVITY ENHANCING COMPOUNDS PROTEOSTASIS THERAPEUTICS, INC. 2021-06-24 — — US disclosed
US-20210188802-A1 PROTEASOME ACTIVITY ENHANCING COMPOUNDS PROTEOSTASIS THERAPEUTICS, INC. 2021-06-24 — — US disclosed
CN-112585130-A Proteasome activity enhancing compounds 蛋白质平衡治疗股份有限公司 2021-03-30 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11746098-B2 Proteasome activity enhancing compounds PSMG3, PSMC1, PSMB11 NOTUM 2817/4885NPC1 2276/4885RAB9A 2592/4885
US-20210188802-A1 PROTEASOME ACTIVITY ENHANCING COMPOUNDS PSMG3, PSMC1, PSMB11 NOTUM 2817/4885NPC1 2276/4885RAB9A 2592/4885
US-20240116894-A1 PROTEASOME ACTIVITY ENHANCING COMPOUNDS PSMG3, PSMC1, PSMB11 NOTUM 2817/4885NPC1 2276/4885RAB9A 2592/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.