SCHEMBL23529344

SCHEMBL23529344

CS(=O)(=O)c1ccc2nc(NC(=O)c3ccc([N+](=O)[O-])s3)sc2c1

nearest known ligand 0.73

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 12/20 0.73
NPC1 O15118 11/20 0.73
SMN1; SMN2 Q16637 7/20 0.73
ALDH1A1 P00352 6/20 0.73
KDM4E B2RXH2 6/20 0.73
TP53 P04637 5/20 0.73
NPSR1 Q6W5P4 2/20 0.73
TSHR P16473 2/20 0.73
POLB P06746 3/20 0.71
MAPT P10636 3/20 0.71
LMNA P02545 2/20 0.71
THRB P10828 1/20 0.71
MEN1 O00255 7/20 0.69
KMT2A Q03164 7/20 0.69
PKM P14618 1/20 0.66
RXFP1 Q9HBX9 4/20 0.60
ACP1 P24666 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23529364 0.84 MAPT (0.73) RAB9ANPC1SMN1; SMN2ALDH1A1POLB
SCHEMBL23529399 0.84 RAB9A (0.72) RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E
SCHEMBL23529400 0.84 RAB9A (0.72) RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E
SCHEMBL23529366 0.84 RAB9A (0.72) RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E
SCHEMBL4918200 0.83 RAB9A (0.71) RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E
SCHEMBL23529343 0.81 RAB9A (0.68) RAB9ANPC1SMN1; SMN2ALDH1A1POLB
SCHEMBL23529381 0.81 RAB9A (0.70) RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E
SCHEMBL6229059 0.79 RAB9A (1.00) RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E
SCHEMBL23529391 0.79 RAB9A (0.67) RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E
SCHEMBL23529350 0.78 RAB9A (0.64) RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12622896-B2 Antiviral compounds, compositions and methods of use THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2026-05-12 US disclosed
US-20230105935-A1 ANTIVIRAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2023-04-06 US disclosed
EP-4077320-A1 ANTIVIRAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE The University of British Columbia (CA) 2022-10-26 EP disclosed
CN-115151536-A Antiviral compounds, compositions and methods of use 不列颠哥伦比亚大学 2022-10-04 CN disclosed
WO-2021119808-A1 ANTIVIRAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2021-06-24 WO disclosed
WO-2021119808-A1 ANTIVIRAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2021-06-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230105935-A1 ANTIVIRAL COMPOUNDS, COMPOSITIONS AND METHODS OF USE SARS1, RNMT, EIF2AK2 RAB9A 3618/4885NPC1 137/4885SMN1; SMN2 2570/4885
US-12622896-B2 Antiviral compounds, compositions and methods of use SARS1, NSUN2, ZC3HAV1 RAB9A 3269/4885NPC1 30/4885SMN1; SMN2 1838/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.