Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KAT7 | O95251 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28837235 | 0.86 | HTT (0.55) | MEN1TSHRKMT2AHTTHDAC1 | |
| SCHEMBL31172538 | 0.81 | HTT (0.52) | MEN1TSHRKMT2AHTTHDAC1 | |
| SCHEMBL13634220 | 0.80 | ALDH1A1 (0.48) | MEN1TSHRKMT2AHTTALDH1A1 | |
| SCHEMBL23631796 | 0.79 | HTT (0.54) | MEN1TSHRKMT2AHTTHDAC1 | |
| SCHEMBL23529840 | 0.77 | HTT (0.47) | MEN1TSHRKMT2AHTTHDAC1 | |
| SCHEMBL5906474 | 0.77 | HTT (0.46) | MEN1TSHRKMT2AHTTHDAC1 | |
| SCHEMBL23529842 | 0.76 | MEN1 (0.44) | MEN1TSHRKMT2AHTTHDAC1 | |
| SCHEMBL1887396 | 0.76 | L3MBTL1 (0.52) | KMT2AALDH1A1MAPTTDP1 | |
| SCHEMBL590781 | 0.76 | TTR (0.47) | MEN1TSHRKMT2AALDH1A1ALOX15 | |
| SCHEMBL28591404 | 0.76 | CA12 (0.43) | MEN1TSHRKMT2AHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113004286-B | Tricyclic compounds as plasma kallikrein inhibitors and uses thereof | 成都康弘药业集团股份有限公司 | 2022-08-12 | — | — | CN | disclosed |
| WO-2021121396-A1 | TRICYCLIC COMPOUND THAT ACTS AS PLASMA KALLIKREIN INHIBITOR AND USE THEREOF | 成都康弘药业集团股份有限公司 | 2021-06-24 | — | — | WO | disclosed |
| CN-113004286-A | Tricyclic compounds as plasma kallikrein inhibitors and uses thereof | 成都康弘药业集团股份有限公司 | 2021-06-22 | — | — | CN | disclosed |