Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.41 |
| ▸ | PARP11 | Q9NR21 | 4/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 5/20 | 0.37 |
| ▸ | ANPEP | P15144 | 2/20 | 0.36 |
| ▸ | IL1RN | P18510 | 1/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23535409 | 0.82 | HTR2C (0.40) | CRBNPARP1KMT2AHTR2CHTR2B | |
| SCHEMBL21997911 | 0.73 | CRBN (0.55) | CRBNPARP1HTR2CHTR2B | |
| SCHEMBL23534354 | 0.73 | CRBN (0.73) | CRBN | |
| SCHEMBL4345609 | 0.72 | CRBN (0.56) | PARP10PARP11CRBNPARP1HTR2C | |
| SCHEMBL5504364 | 0.72 | CRBN (0.39) | CRBNPARP1ANPEPIL1RNERAP2 | |
| SCHEMBL29502600 | 0.71 | CRBN (0.46) | PARP10PARP11CRBNPARP1PDPK1 | |
| SCHEMBL27008204 | 0.71 | CRBN (0.47) | PARP10PARP11CRBNPARP1PDPK1 | |
| SCHEMBL29502372 | 0.71 | CRBN (0.47) | PARP10PARP11CRBNPARP1PDPK1 | |
| SCHEMBL23880787 | 0.68 | IKZF2 (0.45) | — | |
| SCHEMBL4087446 | 0.67 | HTR3A (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021126973-A1 | COMPOUNDS MODULATING PROTEIN RECRUITMENT AND/OR DEGRADATION | ORIONIS BIOSCIENCES, INC. (US) | 2021-06-24 | — | — | WO | disclosed |