SCHEMBL23535482

SCHEMBL23535482

O=C(NCCCN1CCCC1=O)c1ccc(-c2ncc3cnc(-c4cccc(C(F)(F)F)c4)cn23)cc1

nearest known ligand 0.57

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TYRO3 Q06418 1/20 0.47
TSHR P16473 2/20 0.47
ALDH1A1 P00352 1/20 0.47
BRAF P15056 1/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
USP2 O75604 1/20 0.46
SCN9A Q15858 1/20 0.45
LMNA P02545 1/20 0.44
MEN1 O00255 1/20 0.44
HTT P42858 1/20 0.44
KMT2A Q03164 1/20 0.44
HPGD P15428 1/20 0.44
NAMPT P43490 1/20 0.43
ELANE P08246 1/20 0.43
MAPK1 P28482 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30015003 1.00 TYRO3 (0.47) TYRO3TSHRALDH1A1BRAFSMN1; SMN2
SCHEMBL23535610 0.90 NPC1 (0.49) TSHRALDH1A1SMN1; SMN2USP2LMNA
SCHEMBL23535583 0.88 TSHR (0.53) TSHRALDH1A1SMN1; SMN2USP2LMNA
SCHEMBL23535565 0.86 TSHR (0.62) TYRO3TSHRALDH1A1SMN1; SMN2USP2
SCHEMBL23535585 0.81 SMN1; SMN2 (0.55) TSHRALDH1A1SMN1; SMN2USP2LMNA
SCHEMBL23535552 0.79 ALDH1A1 (0.52) TSHRALDH1A1SMN1; SMN2USP2LMNA
SCHEMBL16495574 0.75 TSHR (0.59) TSHRALDH1A1SMN1; SMN2USP2LMNA
SCHEMBL23535523 0.74 FYN (0.49)
SCHEMBL23535518 0.74 FYN (0.45)
SCHEMBL16495441 0.72 TSHR (0.66) TSHRALDH1A1SMN1; SMN2USP2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230056497-A1 CD206 Modulators Their Use and Methods for Preparation US HEALTH (US) 2023-02-23 US disclosed
WO-2021126923-A1 CD206 MODULATORS THEIR USE AND METHODS FOR PREPARATION THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2021-06-24 WO disclosed
WO-2021126923-A1 CD206 MODULATORS THEIR USE AND METHODS FOR PREPARATION THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2021-06-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230056497-A1 CD206 Modulators Their Use and Methods for Preparation CD209, MSR1, ARG1 TYRO3 583/4885TSHR 457/4885ALDH1A1 2010/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.