Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.54 |
| ▸ | RAF1 | P04049 | 3/20 | 0.50 |
| ▸ | BRAF | P15056 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2348622 | 0.92 | MAPK14 (0.54) | MAPK14RAF1BRAFMAPTALDH1A1 | |
| SCHEMBL2350840 | 0.89 | KCNQ2 (0.60) | MAPK14RAF1BRAFMAPTALDH1A1 | |
| SCHEMBL2347316 | 0.87 | MAPK14 (0.54) | MAPK14RAF1BRAFRAB9ANPC1 | |
| SCHEMBL2344412 | 0.84 | MAPK14 (0.57) | MAPK14RAF1BRAFMAPTALDH1A1 | |
| SCHEMBL2349181 | 0.84 | MAPK14 (0.63) | MAPK14RAF1BRAFMAPTALDH1A1 | |
| SCHEMBL2351570 | 0.83 | MAPK14 (0.51) | MAPK14RAF1BRAFMAPTALDH1A1 | |
| SCHEMBL2347606 | 0.83 | MAPK14 (0.55) | MAPK14RAF1BRAFMAPTALDH1A1 | |
| SCHEMBL2342385 | 0.83 | PKM (0.61) | MAPK14RAF1BRAFMAPTALDH1A1 | |
| SCHEMBL2352480 | 0.83 | PKM (0.70) | MAPK14RAF1BRAFMAPTALDH1A1 | |
| SCHEMBL2346273 | 0.82 | RAB9A (0.61) | MAPK14MAPTALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008303-B2 | e.g. 6-Methyl-biphenyl-3,4'-dicarboxylic acid 4'-[(3-bromo-phenyl)-amide]-[(4 morpholin-4-yl-phenyl)-amide]; viricide; with other active viricide such as interferon or ribavirin | ASTRAZENECA AB (SE) | 2011-08-30 | — | — | US | disclosed |