Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 12/20 | 0.45 |
| ▸ | CASP7 | P55210 | 12/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.45 |
| ▸ | GLA | P06280 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 11/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.40 |
| ▸ | USP2 | O75604 | 10/20 | 0.40 |
| ▸ | MEN1 | O00255 | 10/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL239244 | 0.84 | PLAT (0.44) | HSD17B10LMNACYP1A2ALDH1A1HPGD | |
| SCHEMBL239305 | 0.83 | KDM4E (0.41) | CASP1CASP7HSD17B10GLANPC1 | |
| SCHEMBL237744 | 0.70 | PLAT (0.40) | HSD17B10NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL239178 | 0.69 | ALDH1A1 (0.37) | HSD17B10LMNACYP1A2ALDH1A1HPGD | |
| SCHEMBL239223 | 0.67 | PARP1 (0.41) | NPC1RAB9APLATPARP1KDM4E | |
| SCHEMBL2755188 | 0.66 | ALDH1A1 (0.42) | HSD17B10RAB9AALDH1A1KMT2AHPGD | |
| SCHEMBL2755206 | 0.65 | AURKA (0.46) | CASP1CASP7HSD17B10GLANPC1 | |
| SCHEMBL236682 | 0.65 | KDM5B (0.38) | HSD17B10ALDH1A1KMT2AHPGDMAPK1 | |
| SCHEMBL234907 | 0.64 | PLAT (0.36) | HSD17B10ALDH1A1KMT2AHPGDMAPK1 | |
| SCHEMBL1509112 | 0.63 | RAB9A (1.00) | CASP1CASP7HSD17B10GLALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406250-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2015-08-12 | — | — | EP | disclosed |
| EP-2406250-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2015-08-12 | — | — | EP | disclosed |
| US-8614221-B2 | Inhibitors of Akt activity | MERCK SHARP & DOHME CORP. (US) | 2013-12-24 | — | — | US | disclosed |
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME LLC | 2012-01-05 | — | — | US | disclosed |
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME LLC | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | PIK3CD, PIK3CA, PIK3R5 | CASP1 3403/4885CASP7 1082/4885HSD17B10 2830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.