Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17609123 | 1.00 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3FFAR1POLB | |
| SCHEMBL9966337 | 0.92 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3FFAR1POLB | |
| SCHEMBL6907975 | 0.80 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3FFAR1FPR2 | |
| SCHEMBL7705768 | 0.80 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3FFAR1FPR2 | |
| SCHEMBL17892084 | 0.80 | HTR2A (0.47) | SLC6A2SLC6A4SLC6A3FFAR1POLB | |
| SCHEMBL6917685 | 0.80 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3FFAR1FPR2 | |
| SCHEMBL16979039 | 0.80 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3FFAR1FPR2 | |
| SCHEMBL17892086 | 0.80 | HTR2A (0.47) | SLC6A2SLC6A4SLC6A3FFAR1POLB | |
| SCHEMBL14014890 | 0.80 | ALDH1A1 (0.47) | POLBFPR2PROKR1 | |
| SCHEMBL25324799 | 0.79 | FFAR1 (0.51) | SLC6A2SLC6A4SLC6A3FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |