Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 5/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 7/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931973 | 1.00 | OPRL1 (0.41) | OPRL1HTR2AHTR2CHTR2BGRM2 | |
| SCHEMBL23536100 | 0.83 | MEN1 (0.49) | OPRL1HTR2AHTR2CHTR2BGRM2 | |
| SCHEMBL23536127 | 0.80 | ALDH1A1 (0.50) | MAPT | |
| SCHEMBL23536288 | 0.76 | OPRL1 (0.48) | OPRL1HTR2AHTR2CHTR2B | |
| SCHEMBL29931894 | 0.76 | OPRL1 (0.48) | OPRL1HTR2AHTR2CHTR2B | |
| SCHEMBL433273 | 0.73 | OPRL1 (0.59) | OPRL1HTR2AHTR2CHTR2BPROKR1 | |
| SCHEMBL4969208 | 0.73 | OPRL1 (0.64) | OPRL1HTR2AHTR2CHTR2BGRM2 | |
| SCHEMBL23043567 | 0.73 | NOTUM (0.46) | HTR2CNOTUM | |
| SCHEMBL23043670 | 0.73 | MEN1 (0.56) | NOTUMMAPT | |
| SCHEMBL29978740 | 0.73 | NOTUM (0.46) | HTR2CNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |