Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 6/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536137 | 0.84 | GRM2 (0.42) | GRM2OPRL1 | |
| SCHEMBL23536159 | 0.83 | OPRL1 (0.41) | GRM2OPRL1HTR2AHTR2CHTR2B | |
| SCHEMBL29931973 | 0.83 | OPRL1 (0.41) | GRM2OPRL1HTR2AHTR2CHTR2B | |
| SCHEMBL23536030 | 0.82 | GRM2 (0.43) | KMT2AGRM2OPRL1 | |
| SCHEMBL28867411 | 0.82 | OPRL1 (0.42) | MEN1KMT2AGRM2OPRL1ALDH1A1 | |
| SCHEMBL23536314 | 0.82 | GRM2 (0.43) | GRM2OPRL1 | |
| SCHEMBL29931877 | 0.82 | CA2 (0.43) | GRM2OPRL1POLBHTR2AHTR2C | |
| SCHEMBL29932127 | 0.81 | GRM2 (0.43) | KMT2AGRM2OPRL1HTR2AHTR2C | |
| SCHEMBL23536378 | 0.81 | GRM2 (0.43) | KMT2AGRM2OPRL1HTR2AHTR2C | |
| SCHEMBL23536288 | 0.80 | OPRL1 (0.48) | OPRL1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |