Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536314 | 0.79 | GRM2 (0.43) | GRM2ERN1 | |
| SCHEMBL28614790 | 0.78 | DHFR (0.48) | GRM2 | |
| SCHEMBL24105734 | 0.77 | ERN1 (0.50) | ABCB1ERN1KMT2AMEN1 | |
| SCHEMBL30340411 | 0.77 | ERN1 (0.50) | ABCB1ERN1KMT2AMEN1 | |
| SCHEMBL24105749 | 0.76 | ERN1 (0.48) | ABCB1ERN1KMT2AMEN1 | |
| SCHEMBL29931899 | 0.75 | GRM2 (0.44) | GRM2NOTUMABCB1CYP1A2CYP2C9 | |
| SCHEMBL23536325 | 0.75 | GRM2 (0.44) | GRM2NOTUMABCB1CYP1A2CYP2C9 | |
| SCHEMBL23535976 | 0.75 | GRM2 (0.44) | GRM2NOTUMABCB1CYP1A2CYP2C9 | |
| SCHEMBL6223691 | 0.74 | KMT2A (0.41) | NOTUMALDH1A1KMT2AMEN1GAA | |
| SCHEMBL5160655 | 0.74 | MEN1 (0.59) | SMN1; SMN2ALDH1A1KDM4ETSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |