Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931899 | 1.00 | GRM2 (0.44) | GRM2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23535976 | 0.86 | GRM2 (0.44) | GRM2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29932127 | 0.79 | GRM2 (0.43) | GRM2 | |
| SCHEMBL23536378 | 0.79 | GRM2 (0.43) | GRM2 | |
| SCHEMBL23536162 | 0.75 | GRM2 (0.45) | GRM2KDM4EALDH1A1POLBTSHR | |
| SCHEMBL29932096 | 0.73 | ALDH1A1 (0.40) | GRM2KDM4EALDH1A1POLBTSHR | |
| SCHEMBL29931786 | 0.72 | LMNA (0.40) | GRM2KDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL25344389 | 0.69 | NOTUM (0.39) | KDM4EALDH1A1POLBTSHRNOTUM | |
| SCHEMBL11964391 | 0.68 | LMNA (0.47) | KDM4EALDH1A1POLBHSD17B10CYP1A2 | |
| SCHEMBL10994234 | 0.68 | ABCB1 (0.60) | HTR1ASLC6A2SLC6A4SLC6A3ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |