Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BPTF | Q12830 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | MC4R | P32245 | 1/20 | 0.30 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536005 | 1.00 | MEN1 (0.33) | MEN1USP2GAAKMT2ABPTF | |
| SCHEMBL23536158 | 0.86 | GRM2 (0.32) | BPTFC5AR1TRPA1 | |
| SCHEMBL29931942 | 0.86 | GRM2 (0.32) | BPTFC5AR1TRPA1 | |
| SCHEMBL29932072 | 0.81 | ALDH1A1 (0.40) | MEN1GAAKMT2A | |
| SCHEMBL29932032 | 0.81 | ALDH1A1 (0.40) | MEN1GAAKMT2A | |
| SCHEMBL23536037 | 0.81 | ALDH1A1 (0.40) | MEN1GAAKMT2A | |
| SCHEMBL23536151 | 0.81 | ALDH1A1 (0.40) | MEN1GAAKMT2A | |
| SCHEMBL23536058 | 0.79 | CYP2A13 (0.34) | MEN1USP2GAAKMT2ABPTF | |
| SCHEMBL23535973 | 0.79 | CYP2A13 (0.34) | MEN1USP2GAAKMT2ABPTF | |
| SCHEMBL14804508 | 0.78 | BPTF (0.38) | MEN1USP2GAAKMT2ABPTF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |