Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | HPD | P32754 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | AGXT | P21549 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21685600 | 0.87 | HSPB1 (0.51) | HSPB1HPDTDP1ATMMAPK14 | |
| SCHEMBL10789091 | 0.80 | NPC1 (0.68) | RAB9ARECQLNPC1ALDH1A1LMNA | |
| SCHEMBL30069258 | 0.79 | NPC1 (0.62) | RAB9ARECQLNPC1HPDALDH1A1 | |
| SCHEMBL2548000 | 0.78 | NPC1 (0.75) | HSPB1RAB9ARECQLNPC1ALDH1A1 | |
| SCHEMBL1341961 | 0.76 | HSPB1 (0.75) | HSPB1RAB9ARECQLNPC1ALDH1A1 | |
| SCHEMBL8924125 | 0.76 | ALDH1A1 (0.49) | RAB9AALDH1A1LMNATDP1KMT2A | |
| SCHEMBL29447092 | 0.75 | MAPT (0.59) | RAB9ARECQLNPC1ALDH1A1TDP1 | |
| SCHEMBL564270 | 0.75 | MAPT (0.59) | RAB9ARECQLNPC1ALDH1A1TDP1 | |
| SCHEMBL4337112 | 0.75 | HSPB1 (0.58) | HSPB1HPDLMNAIDO1AGXT | |
| SCHEMBL27167067 | 0.75 | POLB (0.57) | HSPB1RAB9ARECQLNPC1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |