Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3096165 | 0.81 | MAPT (0.62) | KMT2AMEN1SMN1; SMN2TSHRLMNA | |
| SCHEMBL23536262 | 0.81 | ALDH1A1 (0.53) | KMT2AMEN1SMN1; SMN2TSHRLMNA | |
| SCHEMBL29931992 | 0.81 | ALDH1A1 (0.53) | KMT2AMEN1SMN1; SMN2TSHRLMNA | |
| SCHEMBL23536131 | 0.81 | ALDH1A1 (0.55) | KMT2AMEN1USP2GAASMN1; SMN2 | |
| SCHEMBL23379676 | 0.77 | GAA (0.63) | KMT2AMEN1USP2GAASMN1; SMN2 | |
| SCHEMBL3070877 | 0.76 | KMT2A (0.56) | KMT2AMEN1USP2GAASMN1; SMN2 | |
| SCHEMBL2771146 | 0.76 | KMT2A (0.56) | KMT2AMEN1USP2GAASMN1; SMN2 | |
| SCHEMBL3090131 | 0.76 | KMT2A (0.56) | KMT2AMEN1USP2GAASMN1; SMN2 | |
| SCHEMBL12082717 | 0.75 | ALDH1A1 (0.50) | KMT2AMEN1SMN1; SMN2TSHRKDM4E | |
| SCHEMBL2077582 | 0.75 | GAA (0.60) | KMT2AMEN1USP2GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |