Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931992 | 1.00 | ALDH1A1 (0.53) | ALDH1A1POLBKMT2ALMNASMN1; SMN2 | |
| SCHEMBL23536206 | 0.83 | ALDH1A1 (0.56) | ALDH1A1KMT2ASMN1; SMN2HTTGRM5 | |
| SCHEMBL29931977 | 0.83 | ALDH1A1 (0.56) | ALDH1A1KMT2ASMN1; SMN2HTTGRM5 | |
| SCHEMBL23536213 | 0.81 | KMT2A (0.56) | ALDH1A1POLBKMT2ALMNASMN1; SMN2 | |
| SCHEMBL23536258 | 0.78 | ALDH1A1 (0.47) | ALDH1A1POLBKMT2ALMNASMN1; SMN2 | |
| SCHEMBL29931922 | 0.78 | ALDH1A1 (0.47) | ALDH1A1POLBKMT2ALMNASMN1; SMN2 | |
| SCHEMBL3096165 | 0.78 | MAPT (0.62) | ALDH1A1POLBKMT2ALMNASMN1; SMN2 | |
| SCHEMBL29788336 | 0.78 | TDP1 (0.69) | ALDH1A1POLBKMT2ALMNAHTT | |
| SCHEMBL2042488 | 0.78 | TDP1 (0.69) | ALDH1A1POLBKMT2ALMNAHTT | |
| SCHEMBL3436153 | 0.76 | MAPT (0.68) | ALDH1A1POLBKMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |