Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 19/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1638693 | 0.85 | CCR1 (0.82) | CCR1CYP2C19KCNH2 | |
| SCHEMBL1690944 | 0.76 | CCR1 (0.66) | CCR1 | |
| SCHEMBL1639478 | 0.76 | CCR1 (0.66) | CCR1 | |
| Ccx354 SCHEMBL30538013 | 0.76 | CCR1 (1.00) | CCR1CYP2C19KCNH2 | |
| Ccx354 SCHEMBL30865101 | 0.76 | CCR1 (1.00) | CCR1CYP2C19KCNH2 | |
| Ccx354 SCHEMBL1638749 | 0.76 | CCR1 (1.00) | CCR1CYP2C19KCNH2 | |
| Ccx354 SCHEMBL29364104 | 0.76 | CCR1 (1.00) | CCR1CYP2C19KCNH2 | |
| SCHEMBL1638044 | 0.76 | CCR1 (0.87) | CCR1CYP2C19KCNH2 | |
| SCHEMBL2353590 | 0.76 | CCR1 (0.57) | CCR1 | |
| SCHEMBL1639499 | 0.74 | CCR1 (0.82) | CCR1CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2352501-A1 | COMPOUNDS FOR THE TREATMENT OF OSTEOPOROSIS AND CANCERS | ChemoCentryx, Inc. (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2010051561-A1 | COMPOUNDS FOR THE TREATMENT OF OSTEOPOROSIS AND CANCERS | CHEMOCENTRYX, INC. (US) | 2010-05-06 | — | — | WO | disclosed |