Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 12/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932011 | 1.00 | NOTUM (0.63) | NOTUMMAPTFFAR4TDP1AKR1C3 | |
| SCHEMBL2072056 | 0.86 | NOTUM (0.83) | NOTUMMAPTTDP1AKR1C3LMNA | |
| SCHEMBL2073619 | 0.85 | NOTUM (0.56) | NOTUMMAPTFFAR4TDP1KMT2A | |
| SCHEMBL29948378 | 0.83 | KMT2A (0.53) | NOTUMMAPTKMT2AHTTL3MBTL1 | |
| SCHEMBL2070466 | 0.82 | NOTUM (0.63) | NOTUMMAPTTDP1AKR1C3LMNA | |
| SCHEMBL9987978 | 0.82 | MAPT (0.56) | NOTUMMAPTFFAR4TDP1KMT2A | |
| SCHEMBL2070458 | 0.82 | NOTUM (0.83) | NOTUMMAPTAKR1C3LMNAHTT | |
| SCHEMBL2070914 | 0.82 | NOTUM (0.59) | NOTUM | |
| SCHEMBL2073585 | 0.81 | NOTUM (0.61) | NOTUMTDP1LMNAHTT | |
| SCHEMBL17542785 | 0.80 | ALDH1A1 (0.56) | MAPTTDP1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |