Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 6/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536180 | 0.84 | KMT2A (0.48) | KMT2ANOTUMMAPTMEN1MALT1 | |
| SCHEMBL29932065 | 0.84 | KMT2A (0.48) | KMT2ANOTUMMAPTMEN1MALT1 | |
| SCHEMBL29932011 | 0.83 | NOTUM (0.63) | KMT2ANOTUMMAPTL3MBTL1HTT | |
| SCHEMBL23536360 | 0.83 | NOTUM (0.63) | KMT2ANOTUMMAPTL3MBTL1HTT | |
| SCHEMBL15056184 | 0.80 | ALDH1A1 (0.57) | KMT2AMAPTHTTALDH1A1 | |
| SCHEMBL23536333 | 0.77 | SSTR2 (0.45) | KMT2ANOTUMMAPTMEN1HTT | |
| SCHEMBL29931979 | 0.77 | SSTR2 (0.45) | KMT2ANOTUMMAPTMEN1HTT | |
| SCHEMBL17542785 | 0.76 | ALDH1A1 (0.56) | KMT2AMAPTMEN1HTTKDM4E | |
| SCHEMBL29948657 | 0.76 | ALDH1A1 (0.56) | KMT2AMAPTMEN1HTTKDM4E | |
| SCHEMBL28867416 | 0.74 | GRM2 (0.41) | KMT2ANOTUMMAPTL3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |