Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29932132 | 1.00 | KMT2A (0.59) | KMT2AHTTALDH1A1MAPTLMNA | |
| SCHEMBL14377179 | 0.99 | HTT (0.58) | KMT2AHTTALDH1A1MAPTLMNA | |
| SCHEMBL10373056 | 0.94 | KMT2A (0.58) | KMT2AHTTALDH1A1MAPTLMNA | |
| SCHEMBL28477963 | 0.89 | HTT (0.51) | KMT2AHTTALDH1A1MAPTLMNA | |
| SCHEMBL14206650 | 0.88 | HTT (0.52) | KMT2AHTTALDH1A1MAPTLMNA | |
| SCHEMBL14335038 | 0.87 | HTT (0.51) | KMT2AHTTALDH1A1MAPTLMNA | |
| SCHEMBL1274938 | 0.84 | HTT (0.73) | KMT2AHTTALDH1A1MAPTLMNA | |
| SCHEMBL3435490 | 0.82 | CTSB (0.52) | KMT2AHTTALDH1A1MAPTLMNA | |
| SCHEMBL3799173 | 0.81 | CTSB (0.65) | KMT2AHTTALDH1A1MAPTLMNA | |
| SCHEMBL29937743 | 0.81 | CTSB (0.65) | KMT2AHTTALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |