Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NMT1 | P30419 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3681530 | 0.76 | SMN1; SMN2 (0.49) | ALDH1A1HTTNPSR1USP2ALOX15 | |
| SCHEMBL17117325 | 0.74 | HTR2C (0.50) | HTR2CHTR2BALDH1A1HTTHTR6 | |
| SCHEMBL23536303 | 0.73 | MAPK14 (0.40) | HTTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL4650978 | 0.71 | SMN1; SMN2 (0.39) | ALDH1A1HTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4770290 | 0.68 | HTR2C (0.50) | HTR2CHTR2BALDH1A1HTTNMT1 | |
| SCHEMBL28867493 | 0.67 | NMT1 (0.38) | HTR2CHTR2BHTR6NMT1 | |
| SCHEMBL20292039 | 0.66 | DDB1 (0.46) | HTR2CMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL14138619 | 0.65 | GPR119 (0.47) | HTR2CHTR2BALDH1A1HTR6MEN1 | |
| Hydrochloric Acid SCHEMBL31510718 | 0.65 | DDB1 (0.45) | HTR2CMEN1KMT2ASMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL4768645 | 0.64 | GBA1 (0.50) | HTR2CHTR2BALDH1A1HTTNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |