Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | SMO | Q99835 | 2/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931843 | 0.88 | MAPK14 (0.35) | MAPK14SMN1; SMN2PDE2ASMOFPR2 | |
| SCHEMBL23536405 | 0.73 | HTR2C (0.39) | HTTSMN1; SMN2LMNAGAAMAPT | |
| SCHEMBL29932243 | 0.72 | LMNA (0.38) | MAPK14HTTSMN1; SMN2LMNATP53 | |
| SCHEMBL23536043 | 0.72 | LMNA (0.38) | MAPK14HTTSMN1; SMN2LMNATP53 | |
| SCHEMBL23536355 | 0.70 | LMNA (0.41) | HTTSMN1; SMN2LMNATP53GAA | |
| SCHEMBL29932092 | 0.70 | LMNA (0.41) | HTTSMN1; SMN2LMNATP53GAA | |
| SCHEMBL23536372 | 0.69 | GPR119 (0.44) | GPR119 | |
| SCHEMBL29931785 | 0.69 | LMNA (0.44) | HTTSMN1; SMN2LMNATP53GAA | |
| SCHEMBL23536592 | 0.69 | LMNA (0.44) | HTTSMN1; SMN2LMNATP53GAA | |
| SCHEMBL30232519 | 0.67 | SLC9A1 (0.37) | GAAMAPTCYP2C9CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |