Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | DTYMK | P23919 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2265663 | 0.87 | P2RX7 (0.48) | PIK3CDALDH1A1HTTNPC1MAPT | |
| SCHEMBL23536422 | 0.79 | PIK3CD (0.56) | PIK3CDALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL734678 | 0.78 | DDB1 (0.44) | ALDH1A1HTTNPC1MAPTMAPK1 | |
| SCHEMBL1571128 | 0.78 | USP2 (0.43) | ALDH1A1MAPTDDB1CRBNUSP2 | |
| SCHEMBL4874324 | 0.77 | DDB1 (0.40) | ALDH1A1HTTNPC1MAPTMAPK1 | |
| SCHEMBL18852406 | 0.77 | PIK3CD (0.58) | PIK3CDALDH1A1HTTNPC1MAPT | |
| SCHEMBL6778385 | 0.77 | DTYMK (0.51) | ALDH1A1HTTNPC1MAPTMAPK1 | |
| SCHEMBL4872722 | 0.77 | DDB1 (0.38) | ALDH1A1HTTNPC1MAPTMAPK1 | |
| SCHEMBL327042 | 0.76 | TP53 (0.50) | L3MBTL1DTYMKGPR119KMT2ATP53 | |
| SCHEMBL4875412 | 0.76 | DDB1 (0.42) | ALDH1A1HTTNPC1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |