Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.56 |
| ▸ | CDC7 | O00311 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | ITK | Q08881 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26912263 | 0.94 | LRRK2 (0.57) | LRRK2CDC7KDM4EALDH1A1MAPK1 | |
| SCHEMBL23536603 | 0.85 | CDC7 (0.45) | LRRK2CDC7KDM4EALDH1A1MAPK1 | |
| SCHEMBL18228562 | 0.84 | HPGD (0.55) | KDM4EALDH1A1MAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL3067812 | 0.84 | HPGD (0.55) | KDM4EALDH1A1MAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL4053256 | 0.83 | HPGD (0.58) | KDM4EALDH1A1MAPK1SMN1; SMN2HSD17B10 | |
| Cyclopropane SCHEMBL27839943 | 0.83 | HPGD (0.58) | KDM4EALDH1A1MAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL29468202 | 0.81 | KDM4E (0.54) | LRRK2KDM4EALDH1A1HSD17B10FGFR1 | |
| SCHEMBL8714004 | 0.81 | PARP1 (0.44) | LRRK2CDC7KDM4EALDH1A1MAPK1 | |
| SCHEMBL1132419 | 0.81 | KDM4E (0.54) | LRRK2KDM4EALDH1A1HSD17B10FGFR1 | |
| SCHEMBL13721430 | 0.81 | PARP1 (0.53) | KDM4EALDH1A1MAPK1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |