Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopropane SCHEMBL27839943 | 1.00 | HPGD (0.58) | HPGDKDM4EMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL18228562 | 0.98 | HPGD (0.55) | HPGDKDM4EMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL3067812 | 0.98 | HPGD (0.55) | HPGDKDM4EMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL1132419 | 0.84 | KDM4E (0.54) | HPGDKDM4EHSD17B10TSHRLMNA | |
| SCHEMBL8714004 | 0.84 | PARP1 (0.44) | HPGDKDM4EMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL29468202 | 0.84 | KDM4E (0.54) | HPGDKDM4EHSD17B10TSHRLMNA | |
| SCHEMBL23536581 | 0.83 | LRRK2 (0.56) | HPGDKDM4EMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL1545498 | 0.83 | CDC7 (0.53) | KDM4EMAPK1ALDH1A1PARP1FLT3 | |
| Hydrochloric Acid SCHEMBL5767318 | 0.83 | KDM4E (0.56) | HPGDKDM4EHSD17B10TSHRLMNA | |
| SCHEMBL10535470 | 0.80 | KMT2A (0.63) | HPGDKDM4EMAPK1HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622480-B2 | Selective H1 histamine receptor antagonists; bronchial asthma, allergic rhinitis, conjunctivitis, dermatitis, urticaria and other allergic diseases; e.g. 3-(4-[1-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]piperidin-1-ylmethyl)benzoic acid | LABORATORIOS ALMIRALL S.A. (ES) | 2009-11-24 | — | — | US | disclosed |
| US-7622480-B2 | Selective H1 histamine receptor antagonists; bronchial asthma, allergic rhinitis, conjunctivitis, dermatitis, urticaria and other allergic diseases; e.g. 3-(4-[1-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]piperidin-1-ylmethyl)benzoic acid | LABORATORIOS ALMIRALL S.A. (ES) | 2009-11-24 | — | — | US | disclosed |
| EP-1497292-B1 | AZAINDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA SA (ES) | 2006-06-14 | — | — | EP | disclosed |
| US-20050176751-A1 | Azaindolylpiperidine derivatives as antihistaminic and antiallergic agents | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-08-11 | — | — | US | disclosed |
| US-20050176751-A1 | Azaindolylpiperidine derivatives as antihistaminic and antiallergic agents | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-08-11 | — | — | US | disclosed |
| EP-1497292-A1 | AZAINDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | Almirall Prodesfarma, S.A. (ES) | 2005-01-19 | — | — | EP | disclosed |
| CN-1143675-C | Heteroarylpiperidines, pyrrolidines and piprazines and their use as antipsychotics and analgetics | ���µ�˹ҩ�﹫˾ | 2004-03-31 | — | — | CN | disclosed |
| WO-2003082867-A1 | AZAINDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA S.A. (ES) | 2003-10-09 | — | — | WO | disclosed |
| US-6376500-B2 | 1-(INDOL-3-YLALKYL)ALKYLPIPERIDIN-4 -YL)-3H-QUINOLIN-4-ONE, FOR EXAMPLE; ALPHA1A/ B-RECEPTOR ANTAGONISTS; SIDE EFFECT REDUCTION; UROGENITAL DISORDERS; BENIGN PROSTATIC HYPERTROPHY; ANALGESICS FOR INFLAMMATORY, NEUROPATHY, CANCER, | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |
| US-20010051627-A1 | Substituted 2-(4-piperidyl)-4(3H)-quinazolinones and 2-(4-piperidyl)- 4(3H)-azaquinazolinones | CLARK ROBIN DOUGLAS (US) | 2001-12-13 | — | — | US | disclosed |
| EP-0135781-B1 | 3-(PIPERIDINYL)- AND 3-(PYRROLIDINYL)-1H-INDAZOLES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS A MEDICAMENT | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-10-11 | — | — | EP | disclosed |
| US-4853470-A | 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-08-01 | — | — | US | disclosed |
| US-4806649-A | ANTIDEPRESSANTS, ANTICONVULSANTS, ANALGESICS, HYPOTENSIVE AGENTS, ANTIHALLUCINOGENS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-02-21 | — | — | US | disclosed |
| US-4775761-A | TREATING PSYCHOSES, DEPRESSION, CONVULSIONS AND HYPERTENSION | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-10-04 | — | — | US | disclosed |
| US-4758668-A | 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-07-19 | — | — | US | disclosed |
| US-4710573-A | PSYCHOLOGICAL DISORDERS | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-12-01 | — | — | US | disclosed |
| US-4670447-A | ANALGESICS, ANTIDEPRESSANTS, ANTICONVULSANTS AND HYPOTENSIVE AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-06-02 | — | — | US | disclosed |
| EP-0192935-A1 | 3-(piperidinyl)-1H-indazoles a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-09-03 | — | — | EP | disclosed |
| EP-0192935-A1 | 3-(piperidinyl)-1H-indazoles a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-09-03 | — | — | EP | disclosed |
| EP-0135781-A1 | 3-(Piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles, a process for their preparation and their use as a medicament | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-04-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176751-A1 | Azaindolylpiperidine derivatives as antihistaminic and antiallergic agents | HRH2, HRH1, HRH4 | HPGD 143/4885KDM4E 1036/4885MAPK1 3220/4885 |
| US-20010051627-A1 | Substituted 2-(4-piperidyl)-4(3H)-quinazolinones and 2-(4-piperidyl)- 4(3H)-azaquinazolinones | ADRA2B, ADRA1D, ADRA1B | HPGD 593/4885KDM4E 2218/4885MAPK1 2289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.