Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 18/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3338109 | 0.78 | MEN1 (0.48) | GPR119POLB | |
| SCHEMBL3640078 | 0.75 | GPR119 (0.57) | GPR119JAK2JAK3PTK2 | |
| SCHEMBL3923864 | 0.73 | GPR119 (0.79) | GPR119JAK2JAK3PTK2 | |
| SCHEMBL20141102 | 0.72 | POLB (0.54) | GPR119POLB | |
| SCHEMBL18282626 | 0.72 | POLB (0.51) | GPR119POLB | |
| SCHEMBL20223124 | 0.71 | MAP4K4 (0.58) | GPR119POLB | |
| SCHEMBL21360402 | 0.71 | POLB (0.53) | GPR119POLB | |
| SCHEMBL8923132 | 0.71 | POLB (0.55) | GPR119POLB | |
| SCHEMBL3436722 | 0.71 | POLB (0.57) | GPR119POLB | |
| SCHEMBL31046329 | 0.71 | POLB (0.57) | GPR119POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |