Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL169420 | 0.82 | IDO1 (0.50) | IDO1ARPOLQKDM4EALDH1A1 | |
| SCHEMBL31751977 | 0.82 | GABRA1 (0.46) | CTSSP2RX7TAS2R14CYP2D6SLC6A2 | |
| SCHEMBL11967099 | 0.82 | GABRA1 (0.46) | CTSSP2RX7TAS2R14CYP2D6SLC6A2 | |
| SCHEMBL377351 | 0.81 | AKR1B1 (0.43) | CTSSP2RX7IDO1 | |
| SCHEMBL6862729 | 0.81 | IDO1 (0.38) | CTSSSCN8AIDO1POLQCMA1 | |
| SCHEMBL2360363 | 0.80 | GABRA1 (0.41) | CTSSSLC6A2SLC6A4IDO1AR | |
| SCHEMBL13437613 | 0.80 | P2RX7 (0.42) | CTSSP2RX7SLC6A2SLC6A4 | |
| SCHEMBL18753207 | 0.79 | IDO1 (0.41) | CTSSP2RX7TAS2R14CYP2D6SLC6A2 | |
| SCHEMBL4550354 | 0.77 | MAOB (0.45) | P2RX7TAS2R14CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL737569 | 0.77 | PDCD1 (0.48) | CTSSP2RX7TAS2R14CYP2D6SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4110333-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-01-04 | — | — | EP | disclosed |
| EP-4076418-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2022187236-A1 | NOVEL SUBSTITUTED TRICYCLIC AZA-HETEROCYCLES AS SOS1 INHIBITORS | VIVA STAR BIOSCIENCES (SUZHOU) CO., LTD. (CN) | 2022-09-09 | — | — | WO | disclosed |
| WO-2021127429-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2021-06-24 | — | — | WO | disclosed |